The distribution of cutaneous metastases correlates with local immunologic milieu
Identifieur interne : 000A22 ( Main/Exploration ); précédent : 000A21; suivant : 000A23The distribution of cutaneous metastases correlates with local immunologic milieu
Auteurs : Joshua M. Schulman [États-Unis] ; Mariela L. Pauli [États-Unis] ; Isaac M. Neuhaus [États-Unis] ; Roberto Sanchez Rodriguez [États-Unis] ; Keyon Taravati [États-Unis] ; Uk Sok Shin [États-Unis] ; Timothy H. Mccalmont [États-Unis] ; Michael D. Rosenblum [États-Unis]Source :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 2016.
Abstract
Metastases to the skin are found with increased frequency at certain sites, such as the scalp, but the biological factors that influence this distribution are not understood.
We aimed to compare the proportional frequency of metastases at various cutaneous locations with the immunologic microenvironments at those sites.
We retrospectively identified all biopsies of cutaneous metastases diagnosed at our institution from 1991 to 2014 (n = 1984) and mapped their anatomic distribution while controlling for regional surface area. Using a separate, mapped cohort of normal skin samples (n = 140), we measured the density of regulatory T cells (Tregs), CD4+ effector T cells, and CD8+ T cells by flow cytometry.
Per unit surface area, cutaneous metastases arise most commonly on the head and neck, followed by the trunk, upper extremities, and lower extremities, respectively. Sites with more frequent metastases tend to contain a greater density of Tregs and a lower proportion of CD8+ T cells (p < 0.05).
Immunologic factors were only assessed in control tissue and were not measured from patients with metastatic disease in this correlative single-center study.
The distribution of cutaneous metastases follows the distribution of regulatory and effector T cells in skin. Further studies are required to prove a mechanistic association between local immunologic factors and the development of cutaneous metastases.
Url:
DOI: 10.1016/j.jaad.2015.10.012
PubMed: 26778012
PubMed Central: 4761273
Affiliations:
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Schulman</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Department of Pathology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Pathology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Pauli, Mariela L" sort="Pauli, Mariela L" uniqKey="Pauli M" first="Mariela L." last="Pauli">Mariela L. 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Schulman</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Department of Pathology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Pathology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Pauli, Mariela L" sort="Pauli, Mariela L" uniqKey="Pauli M" first="Mariela L." last="Pauli">Mariela L. Pauli</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Neuhaus, Isaac M" sort="Neuhaus, Isaac M" uniqKey="Neuhaus I" first="Isaac M." last="Neuhaus">Isaac M. Neuhaus</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Rodriguez, Roberto Sanchez" sort="Rodriguez, Roberto Sanchez" uniqKey="Rodriguez R" first="Roberto Sanchez" last="Rodriguez">Roberto Sanchez Rodriguez</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Taravati, Keyon" sort="Taravati, Keyon" uniqKey="Taravati K" first="Keyon" last="Taravati">Keyon Taravati</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Shin, Uk Sok" sort="Shin, Uk Sok" uniqKey="Shin U" first="Uk Sok" last="Shin">Uk Sok Shin</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Mccalmont, Timothy H" sort="Mccalmont, Timothy H" uniqKey="Mccalmont T" first="Timothy H." last="Mccalmont">Timothy H. Mccalmont</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Department of Pathology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Pathology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Rosenblum, Michael D" sort="Rosenblum, Michael D" uniqKey="Rosenblum M" first="Michael D." last="Rosenblum">Michael D. Rosenblum</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Dermatology, University of California, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Dermatology, University of California</wicri:orgArea></affiliation></author></analytic><series><title level="j">Journal of the American Academy of Dermatology</title><idno type="ISSN">0190-9622</idno><idno type="eISSN">1097-6787</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Metastases to the skin are found with increased frequency at certain sites, such as the scalp, but the biological factors that influence this distribution are not understood.</p></sec><sec id="S2"><title>Objective</title><p id="P2">We aimed to compare the proportional frequency of metastases at various cutaneous locations with the immunologic microenvironments at those sites.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We retrospectively identified all biopsies of cutaneous metastases diagnosed at our institution from 1991 to 2014 (n = 1984) and mapped their anatomic distribution while controlling for regional surface area. Using a separate, mapped cohort of normal skin samples (n = 140), we measured the density of regulatory T cells (Tregs), CD4+ effector T cells, and CD8+ T cells by flow cytometry.</p></sec><sec id="S4"><title>Results</title><p id="P4">Per unit surface area, cutaneous metastases arise most commonly on the head and neck, followed by the trunk, upper extremities, and lower extremities, respectively. Sites with more frequent metastases tend to contain a greater density of Tregs and a lower proportion of CD8+ T cells (p < 0.05).</p></sec><sec id="S5"><title>Limitations</title><p id="P5">Immunologic factors were only assessed in control tissue and were not measured from patients with metastatic disease in this correlative single-center study.</p></sec><sec id="S6"><title>Conclusion</title><p id="P6">The distribution of cutaneous metastases follows the distribution of regulatory and effector T cells in skin. Further studies are required to prove a mechanistic association between local immunologic factors and the development of cutaneous metastases.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>San Francisco</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Schulman, Joshua M" sort="Schulman, Joshua M" uniqKey="Schulman J" first="Joshua M." last="Schulman">Joshua M. Schulman</name></region><name sortKey="Mccalmont, Timothy H" sort="Mccalmont, Timothy H" uniqKey="Mccalmont T" first="Timothy H." last="Mccalmont">Timothy H. Mccalmont</name><name sortKey="Mccalmont, Timothy H" sort="Mccalmont, Timothy H" uniqKey="Mccalmont T" first="Timothy H." last="Mccalmont">Timothy H. Mccalmont</name><name sortKey="Neuhaus, Isaac M" sort="Neuhaus, Isaac M" uniqKey="Neuhaus I" first="Isaac M." last="Neuhaus">Isaac M. Neuhaus</name><name sortKey="Pauli, Mariela L" sort="Pauli, Mariela L" uniqKey="Pauli M" first="Mariela L." last="Pauli">Mariela L. Pauli</name><name sortKey="Rodriguez, Roberto Sanchez" sort="Rodriguez, Roberto Sanchez" uniqKey="Rodriguez R" first="Roberto Sanchez" last="Rodriguez">Roberto Sanchez Rodriguez</name><name sortKey="Rosenblum, Michael D" sort="Rosenblum, Michael D" uniqKey="Rosenblum M" first="Michael D." last="Rosenblum">Michael D. Rosenblum</name><name sortKey="Schulman, Joshua M" sort="Schulman, Joshua M" uniqKey="Schulman J" first="Joshua M." last="Schulman">Joshua M. Schulman</name><name sortKey="Shin, Uk Sok" sort="Shin, Uk Sok" uniqKey="Shin U" first="Uk Sok" last="Shin">Uk Sok Shin</name><name sortKey="Taravati, Keyon" sort="Taravati, Keyon" uniqKey="Taravati K" first="Keyon" last="Taravati">Keyon Taravati</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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